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cssR [2019-02-01 12:05:09]
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cssR [2019-02-01 12:05:09]

two-component response regulator ([SW|OmpR family]), control of cellular responses to [SW|protein secretion] stress
locus
BSU33010
pI
5.07
mw
26.06 kDa
protein length
225 aa Sequence Blast
gene length
678 bp Sequence Blast
function
control of cellular responses to protein secretion stress
product
two-component response regulator ([SW|OmpR family])
essential
no
synonyms
yvqA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

    • Gene

    Coordinates
    3,385,724 3,386,401

    The protein

    Protein family

  • [SW|OmpR family] of two-component response regulators

    • Modification

  • phosphorylated by [protein|4EE48E4931F662E51586DB6D01E91C688329222D|CssS] on an Asp residue

    • Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • additional information

  • [protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR] may interact with [SW|RNA polymerase] [pubmed|21710567]

    • Expression and Regulation

    Operons

    genes
    [gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]-[gene|4EE48E4931F662E51586DB6D01E91C688329222D|cssS]
    description
    [Pubmed|11555295]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|12270824], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR]: activation, [Pubmed|12270824], in [regulon|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR regulon]

    • regulation

  • expressed under conditions of secretion stress ([protein|search|CssR]) [Pubmed|12270824]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-B031 (yvqA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1030 NBRP B. subtilis, Japan]
  • BKE33010 ([gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT, downstream forward: _UP4_TTCGGCTACAGGATGATGTC
  • BKK33010 ([gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT, downstream forward: _UP4_TTCGGCTACAGGATGATGTC

    • References

    Reviews

  • 27518094

    • Original Publications

  • 10094672,17600057,21710567,17088376,12270824,12270824,11555295,19820159,21602801,21624103,21710567